Dr. H.K. Prasad
Retired :
Professor,
Department of Biotechnology,
All India Institute of Medical Sciences (AIIMS),
Ansari Nagar,
New Delhi-110029
Current Position: Emeritus Medical Scientist (ICMR)
Education:
M.Sc. - A.I.I.M.S., New Delhi; 1975
Ph.D - A.I.I.M.S., New Delhi; 1981
Fellowships:
- Victor Hessier Post Doctoral Fellowship- DBT Short term over seas fellowship
Elected Member: Guha Research Conference 2006
Member of Scientific Societies:
a. Life member Indian Immunology Society
b. Life member Molecular Immunology Forum
c. Life Member Society of Biological Chemists, India
d. Society for Scientific Values
e. American Society for Microbiology
Committee Member: ICMR, DBT
Teaching / Research Experience:
Date |
Location |
Organization |
Position |
Responsibilities |
1979-1981 |
New Delhi, India |
All India Institute of Medical Sciences |
Junior Research Fellow |
Research |
1981-1983 |
New York, USA |
Heisser Foundation |
Post Doctoral Fellow |
Research |
1983-1987 |
New Delhi, India |
Indian Council of Medical Research |
Senior Research Officer |
Research & Teaching |
1987-1988 |
New Delhi, India |
All India Institute of Medical Sciences |
Senior Research Officer |
Research & Teaching |
1988-1992 |
New Delhi, India |
All India Institute of Medical Sciences |
Associate Professor |
Research & Teaching |
1992-2001 |
New Delhi, India |
All India Institute of Medical Sciences |
Additional Professor |
Research & Teaching |
2001-2015 | New Delhi, India |
All India Institute of Medical Sciences |
Professor |
Research & Teaching |
Significant Contribution:
-- Discovery and description of the HupB gene (Rv 2986c) of M. tuberculosis, a histone like DNA binding protein.
-- Differences between HupB gene (Rv 2986c) of M. tuberculosis and M. bovis (Mb 3010c) has been exploited for direct identification.
-- The development of a nested PCR assay for direct detection of M. tuberculosis and M. bovis in bovine and human clinical samples.
-- The potential possibilities of the occurrence of Zoonotic and reverse Zoonotic tuberculosis
-- Cytokine function generation and function in tuberculosis
Publications:
Research Papers: 42
Others: Chapter in Book: 3
International Patents: Three
Research supervision:
Ph.D. Thesis
Completed - 10
M. Biotech. Dissertations: 40
Key Activities:
i. Teaching : Immunology for Masters in Biotechnology
ii. Research : Immunology of Tuberculosis; Diagnosis of Tuberculosis
Current research efforts:
(i) To establish the complex web of mycobacterial transmission that could potentially occur between humans and domesticated animals; and the reservoirs of infection that maintain the pathogens in the environment. In order to establish transmission of pathogens from humans to cattle and cattle to humans efforts are on to identify and trace the origin of strains of mycobacterial pathogens isolated from clinical samples.
(ii) Role of type I interferons in tuberculosis.
Publications:
1. Das S, Roychowdhury T, Kumar P, Kumar A, Kalra P, Singh J, Singh S, Prasad HK, Bhattacharya A. Genetic heterogeneity revealed by sequence analysis of Mycobacterium tuberculosis isolates from extra-pulmonary tuberculosis patients. BMC Genomics. 2013 Jun 17;14:404.
2. Saini C, Prasad HK, Rani R, Murtaza A, Misra N, Narayan NPS, Nath. Lsr2 of Mycobacterium leprae and Its Synthetic Peptides Elicit Restitution of T Cell Responses in Erythema Nodosum Leprosum and Reversal Reactions in Patients with Lepromatous Leprosy. Clin. Vaccine Immunol. 2013 May: 20(5):673-82.
3. Verma VK, Taneja V, Jaiswal A, Sharma S, Behera D, Sreenivas V, Chauhan SS, Prasad HK. Prevalence, Distribution and Functional Significance of the - 237C to T Polymorphism in the IL-12Rß2 Promoter in Indian Tuberculosis Patients. PLoS One. 2012 April; 7(4):e34355.
4. Das S, Duggal P, Roy R, Myneedu VP, Behera D, Prasad HK, Bhattacharya A. Identification of Hot and Cold spots in genome of Mycobacterium tuberculosis using Shewhart Control Charts. Sci. Rep. 2, 297; DOI:10.1038/srep00297 (March 2012).
5. Kumar P, Sen MK, Chauhan DS, Katoch VM, Singh S, Prasad HK. Assessment of the N-PCR assay in diagnosis of pleural tuberculosis: Detection of M. tuberculosis in pleural fluid and sputum collected in tandem. PLoS ONE 2010; 5(4):e10220.